产品货号：
Z11625
中文名称：
ASAH1抗体
英文名称：
Anti-ASAH1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ASAH1 Antibody |
| 指标别名 | AC;Acid ceramidase;Acylsphingosine deacylase;ASAH;ASAH1;HSD 33;PHP;PHP32;Putative 32kDa heart protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | ASAH1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | ASAH1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of the human ASAH1.The immunogen is located within amino acids 240 - 290 of ASAH1. |
| 计算分子量 | 45kDa |
| 成分 | ASAH1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ASAH1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids.These ceramidases are classified according to the pHrange that supports their optimal activity.ASAH1 is an acid ceramidase and key regulator of ceramide metabolism.Mutations in this gene results in Farber Lipogranulomatosis,a fatal human genetic disorder that results in the painful swelling of the joints and tendons and pulminary insufficiency,while a complete knockout of its expression is lethal in mice.Recent studies have shown elevated levels of ASAH1 in Alzheimer's disease (AD) patients correlating with a reduction in sphingomyelin and elevation of ceramide.Pretreatment of cultured neurons with recombinant AHAH1 prevented the cells from undergoing A-beta (Ab)-induced apoptosis. |
| Uniprot ID | Q13510 |
| 基因名全称 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 |
| 蛋白名全称 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 |
| 推荐稀释比 | ASAH1 antibody can be used for detection of ASAH1 by Western blot at 1 and 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human and rat samples and Immunofluorescence in human and rat samples.All other applications and species not yet tested. |
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